Effects of General Anesthesia Combined with Epidural Anesthesia on Cognitive Dysfunction and Inflammatory Markers of Patients after Surgery for Esophageal Cancer: A Randomised Controlled Trial

Objective To evaluate the impact of general anesthesia (GA) combined with epidural (GAEA) on postoperative cognitive dysfunction (POCD) and inflammatory markers in patients esophageal cancer (EC). Study Design: A randomised controlled trial. Place duration study Department Anesthesiology, Traditional Chinese Medicine Hospital Southwest Medical University, Luzhou, Sichuan Province, China, from August 2019 to April 2020. Methodology SPSS was used randomly divide 142 cases into two groups, namely: GA (n=71) GAEA categories. 128 candidates were this study. Cognitive function levels interleukin 6 (IL-6), 8 (IL-8), tumor necrosis α (TNF-α) serum evaluated at baseline, 1, 3 7 days after operation by Montreal Assessment (MoCA) enzyme-linked immunosorbent assay (ELISA), respectively. Pearson correlation analysis assess interrelationships between MoCA score levels. Results Compared group (n=64), category (n=64) showed significantly higher 1 day postoperatively (all p 0.05). Conclusion Combining may reduce incidence POCD undergoing esophagectomy suppressing response. Key Words: General anesthesia, Epidural Esophageal cancer, Postoperative dysfunction, Inflammatory markers.